4-Benzyl-2,6-dichloropyrimidine synthesis
- Product Name:4-Benzyl-2,6-dichloropyrimidine
- CAS Number:796095-89-1
- Molecular formula:C11H8Cl2N2
- Molecular Weight:239.1
3764-01-0
400 suppliers
$6.00/5g
6921-34-2
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$74.79/50ml
796095-89-1
36 suppliers
$427.00/1g
Yield:796095-89-1 92%
Reaction Conditions:
in tetrahydrofuran;diethyl ether at -78 - 20; for 3 h;
Steps:
51 Preparation 51: 4-benzyl-2,6-dichloropyrimidine (P51)
To a solution of 2,4,6-trichloropyrimidine (936 mg, 5 mmol) in THE (30 mL) 1M benzylmagnesiumchloride in Et20 (5mL, 5 mmol) was added dropwise at -78 °C. The reaction was allowed to warm up to 20 °C over 3 hrs. EtOAc and H20 were added, the product was extracted twice in organic phase, which was dried and evaporated. The crude material was purified by EC on silica (eluent:Cy to Cy/EA 90/10) affording 4-benzyl-2,6-dichloropyrimidine (p51, 1.1 g, y= 92%) as pale yellow oil.1H NMR (CHLOROFORM-d): 6 ppm 7.44 - 7.32 (m, 3H), 7.30 - 7.24 (m, 2H), 7.04 (s, 1H), 4.12 (s, 2H)
References:
WO2016/42452,2016,A1 Location in patent:Page/Page column 117
3764-01-0
400 suppliers
$6.00/5g
1589-82-8
155 suppliers
$60.00/5g
796095-89-1
36 suppliers
$427.00/1g
100-39-0
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$10.00/10g
796095-89-1
36 suppliers
$427.00/1g