(4-Benzyl-piperazin-1-yl)-acetic acid Methyl ester synthesis
1synthesis methods
- Product Name:(4-Benzyl-piperazin-1-yl)-acetic acid Methyl ester
- CAS Number:179869-10-4
- Molecular formula:C14H20N2O2
- Molecular Weight:248.32
Yield:-
Reaction Conditions:
with triethylamine in methanol;
Steps:
XI.a a
a Methyl (4-benzyl-piperazin-1-yl)-acetate A solution of 6 g (0.034 mol) of N-benzyl-piperazine (6 ml), 5.2 g (0.034 mol) of methyl bromoacetate (3.3 ml) and 3.5 g (0.034 mol) of triethylamine (4.8 ml) in 100 ml of methanol is left to stand overnight at room temperature. The solution is then concentrated to dryness in vacuo and the residue is purified over a silica gel column (eluding agent: methylene chloride which contains 2% of methanol). Yield: 7 g of an oil (82.8% of theory), Rf value: 0.60 (silica gel; methylene chloride/methanol/concentrated ammonia=9:1:0.1)
References:
US5922717,1999,A