ChemicalBook CAS DataBase List 4-Benzyloxy-2,3-difluorobenzoicacid

4-Benzyloxy-2,3-difluorobenzoicacid synthesis

5synthesis methods

Product Name:4-Benzyloxy-2,3-difluorobenzoicacid
CAS Number:144292-54-6
Molecular formula:C14H10F2O3
Molecular Weight:264.22

100-39-0
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Yield:144292-54-6 74.6%

Reaction Conditions:

with caesium carbonate in N,N-dimethyl-formamide at 20; for 24 h;Cooling with ice;

Steps:

int-1-1-b An intermediate compound 1-1-b (4-(benzyloxy ) -2, 3-difluorobenzoic acid ) synthesis of

Cesium carbonate excess of the catalyst base (56.14g, 172.3mmol) and methyl 2, 3-difluoro-4-hydroxybenzoic acid (15g, 86.2mmol) for N, paste has better mouth feeling and agitating N-dimethylformamide was dissolved. Then the first bath freezing (ice bath) using benzyl bromide (10.3 ml, 86.2mmol) a blended 24 houses an mix solution which is then reacted time at room temperature. Excess distilled water of agent is placed a request of the reaction, until is pH2 to the precipitation the dripped into HCl. To filter out precipitate a solid product in the form of a powder (yield: 74.6%)of title compound are obtained.

References:

KR2015/105610,2015,A Location in patent:Paragraph 0097-0099

6418-38-8 Synthesis