ChemicalBook CAS DataBase List 4-(Benzyloxy)-2-fluorobenzaldehyde

4-(Benzyloxy)-2-fluorobenzaldehyde synthesis

3synthesis methods

Product Name:4-(Benzyloxy)-2-fluorobenzaldehyde
CAS Number:504414-32-8
Molecular formula:C14H11FO2
Molecular Weight:230.23

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100-39-0
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504414-32-8
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Yield:504414-32-8 94.4%

Reaction Conditions:

with caesium carbonate in N,N-dimethyl-formamide at 20; for 72 h;

Steps:

2.1

Example 2: 10-acetyl-l l-(4-benzyloxy-2-fluorophenyl)-3,3-dimethyl-l,l-dioxo- 1,2,3,4,5,1 l-hexahvdro-lλ⁶-thia-5J0-diazadibenzorα,?cvcloheptene (13); Step 1; A mixture of 2-fluoro-4-hydroxybenzaldehyde (2.92 mmol), benzylbromide (534 μL, 4.38 mmol) and Cs₂CO₃ (1.14 g, 3.50 mmol) in dry DMF (N,N-dimethylformamide; 10 niL) was stirred at room temperature for 3 days. Then, the reaction mixture was diluted with water (200 mL). The resulting precipitate was filtered off, then dried under vacuum to give the desired product 4-benzyloxy-2-fluorobenzaldehyde (11) (94.4 %) as a white solid: m/z = 231 (M+H)⁺.

References:

WO2008/99020,2008,A1 Location in patent:Page/Page column 49-50

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504414-32-8
54 suppliers
$42.00/250mg

References

504414-33-9
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504414-32-8
54 suppliers
$42.00/250mg

References