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4'-BENZYLOXY-2'-HYDROXY-3'-METHYLACETOPHENONE synthesis

3synthesis methods
Preparation by reaction of benzyl chloride on 2,4-di-hydroxy-3-methylacetophenone with potassium carbonate and potassium iodide in refluxing acetone (81%).
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Yield:73640-74-1 95%

Reaction Conditions:

Stage #1: 1-(2,4-dihydroxy-3-methylphenyl)ethanonewith potassium carbonate;potassium iodide in acetone at 50; for 0.5 h;
Stage #2: benzyl bromide in acetone; for 5 h;Reflux;

References:

Hartmann, Markus;Huber, Jessica;Kramer, Jan S.;Heering, Jan;Pietsch, Larissa;Stark, Holger;Odadzic, Dalibor;Bischoff, Iris;Fürst, Robert;Schr?der, Martin;Akutsu, Masato;Chaikuad, Apirat;D?tsch, Volker;Knapp, Stefan;Biondi, Ricardo M.;Rogov, Vladimir V.;Proschak, Ewgenij [Journal of Medicinal Chemistry,2021,vol. 64,# 7,p. 3720 - 3746]

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