(4-BENZYLOXY-3,5-DIMETHYL-PHENYL)-METHANOL synthesis
- Product Name:(4-BENZYLOXY-3,5-DIMETHYL-PHENYL)-METHANOL
- CAS Number:773868-60-3
- Molecular formula:C16H18O2
- Molecular Weight:242.31
144896-51-5
59 suppliers
$35.29/1g
773868-60-3
13 suppliers
inquiry
Yield:773868-60-3 96%
Reaction Conditions:
Stage #1: 3,5-dimethyl-4-benzyloxy benzaldehydewith sodium tetrahydroborate in methanol at 0 - 20;
Stage #2: with hydrogenchloride in water;
Steps:
3.3.2
Step 2; 3,5-dimethyl-4-benzyloxyphenylmethanol; Sodium borohydride (14.2 g; 0.374 mol) was slowly added to a solution of this aldehyde (60.0 g; 0.375 mol) in methanol (200 ml) previously cooled to 0° C. with an ice bath. The ice bath was then removed and stirring was maintained at room temperature until the end of gas evolution. Solvant was evaporated and 10% hydrochloric acid was slowly added to neutralize the mixture. The product was extracted with dichloromethane and washed with NaClsat. The organic layer was dried with magnesium sulfate (MgSO4) and evaporated. The obtained oil was used without further purification. Yield: 96%
References:
US2006/79696,2006,A1 Location in patent:Page/Page column 45-46
773873-94-2
8 suppliers
inquiry
773868-60-3
13 suppliers
inquiry
97888-80-7
64 suppliers
$50.00/500g
773868-60-3
13 suppliers
inquiry