4-BENZYLOXY-3-CHLORO NITROBENZENE 97 synthesis
- Product Name:4-BENZYLOXY-3-CHLORO NITROBENZENE 97
- CAS Number:50508-54-8
- Molecular formula:C13H10ClNO3
- Molecular Weight:263.68
350-30-1
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100-51-6
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50508-54-8
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$720.00/100g
Yield:50508-54-8 97%
Reaction Conditions:
with potassium hydroxide in acetonitrile at 45; for 14 h;
Steps:
1.b EXAMPLE 1b
EXAMPLE 1b To prepare 4-(benzyloxy)3-chloronitrobenzene, benzyl alcohol (0.34 kg, 3.14 mole, 1.10 eq) was dissolved in acetonitrile (1.70 L) and to it was added potassium hydroxide flakes (85%) (0.24 kg, 1.50 eq). The resulting suspension was warmed to 25° C. A solution of the 3-chloro-4-fluoronitrobenzene (0.50 kg, 2.85 mol, 1.0 eq) in acetonitrile (0.75 L) was added keeping the pot temperature<45° C. The mixture was held for 14 h. The mixture was then cooled back to 0-15° C., quenched with water (2.5 L) and the resulting slurry was filtered and washed with water (2*0.50 L).
References:
US2006/270668,2006,A1 Location in patent:Page/Page column 16
619-08-9
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100-39-0
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50508-54-8
23 suppliers
$720.00/100g
38731-70-3
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100-44-7
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$13.50/250G
50508-54-8
23 suppliers
$720.00/100g