4-BENZYLOXY-3-NITRO-BENZALDEHYDE synthesis
- Product Name:4-BENZYLOXY-3-NITRO-BENZALDEHYDE
- CAS Number:22955-07-3
- Molecular formula:C14H11NO4
- Molecular Weight:257.24
Yield:22955-07-3 95%
Reaction Conditions:
with potassium carbonate in N,N-dimethyl-formamide;
Steps:
Synthesis of Compound 74
Synthesis of Compound 74 To a suspension of 4-hydroxy-3-nitrobenzaldehyde 73 (3.00 g, 17.95 mmol), potassium carbonate (3.73 g, 26.93 mmol) in DMF (300 mL) was slowly added benzyl bromide (2.85 mL, 23.96 mmol). The reaction mixture was stirred at 65° C. for 18 hours. After cooling to room temperature, the mixture was diluted with water (140 mL) and extracted with diethyl ether (3*150 mL). The combined organic layers were washed with water (150 mL) and brine (150 mL). After drying over anhydrous MgSO4, filtration and evaporation of the filtrate in vacuo gave crude compound 74 (4.393 g, 95%) which was used for the next reaction without further purification.
References:
US2003/186943,2003,A1
