4-[(BENZYLOXY)METHYL]PIPERIDINE HYDROCHLORIDE synthesis

Yield: 84%

Reaction Conditions:

with hydrogenchloride in 1,4-dioxane at 20; for 1.5 h;

Steps:

48 Production Example 48; 4-[(Benzyloxy)methyl]piperidine monohydrochloride
Production Example 48 4-[(Benzyloxy)methyl]piperidine monohydrochloride To 3.4 g (11.1 mmol) of the compound obtained in Production Example 47, 11.3 ml of a 4N-hydrochloric acid/1,4-dioxane solution was added, and the mixture was stirred at room temperature for 1.5 hours.. Then, ether was gradually added, and precipitated solids were collected by filtration to obtain 1.26 g (84%) of the captioned compound.

References:

Daiichi Suntory Pharma Co., Ltd.;Daiichi Suntory Biomedical Research Limited EP1454897, 2004, A1 Location in patent:Page 27