(4-(Benzyloxy)phenyl)(piperidin-4-yl)Methanone synthesis

Yield:1263378-61-5 234 mg

Reaction Conditions:

with trifluoroacetic acid in dichloromethane; for 3 h;

Steps:

Intermediate 139: (4-Benzyloxy-phenyl)-piperidin-4-yl-methanone

Intermediate 139: (4-Benzyloxy-phenyl)-piperidin-4-yl-methanoneThe a solution of 4-(4-benzyloxy-benzoyl)-piperidine-1 -carboxylic acid tert-butyl ester (313 mg, 0.79 mmol) in dichloromethane (10 mL) was added TFA (0.61 mL, 7.9 mmol). The reaction was stirred for 3 hours and then the solvent removed under vacuum and placed under high vacuum to afford the title compound (234 mg). LRMS m/z : ES+ = 295.9 (M+H), retention time 1 .18.

References:

WO2013/12723,2013,A1 Location in patent:Page/Page column 92