ChemicalBook CAS DataBase List 4-BENZYLOXYANILINE

4-BENZYLOXYANILINE synthesis

9synthesis methods

Product Name:4-BENZYLOXYANILINE
CAS Number:6373-46-2
Molecular formula:C13H13NO
Molecular Weight:199.25

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6373-46-2
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Yield:6373-46-2 93%

Reaction Conditions:

with potassium hydroxide in ethanol;waterReflux;

Steps:

General Procedure F.
General procedure: An acetamide (4 mmol) along with KOH (40 mmol) and 9:1 DI water/ethanol (50 mL) was refluxed overnight. After the reaction was complete, the ethanol was removed under reduced pressure. The residue was then dissolved in DCM washed with DI water, dried over Na2SO4, filtered, and concentrated under reduced pressure. The resulting oil could then be used without further purification in most cases. If not, aqueous HCl was added and the solution was washed with EA. The aqueous layer was basified and then washed with EA, and the organic layer was dried over Na2SO4, filtered, and concentrated under reduced pressure.

References:

University of South Florida;Northeastern University;Manetsch, Roman;Kyle, Dennis E.;Neelarapu, Raghupathi;Maignan, Jordany R.;Lichorowic, Cynthia L.;LaCrue, Alexis N. US10000452, 2018, B1 Location in patent:Page/Page column 103

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1145-76-2 Synthesis