ChemicalBook CAS DataBase List 4-BOC-AMINOMETHYLPHENYLACETIC ACID

4-BOC-AMINOMETHYLPHENYLACETIC ACID synthesis

12synthesis methods

Product Name:4-BOC-AMINOMETHYLPHENYLACETIC ACID
CAS Number:71420-92-3
Molecular formula:C14H19NO4
Molecular Weight:265.3

24424-99-5 Synthesis

24424-99-5
840 suppliers
$13.50/25G

1200-05-1 Synthesis

1200-05-1
58 suppliers
$82.00/100 mg

71420-92-3
81 suppliers
$98.00/100mg

Yield:71420-92-3 53%

Reaction Conditions:

with sodium hydroxide in 1,4-dioxane;water at 20; for 24 h;

Steps:

16.b Step b. 2-(4-(((Tert-butoxycarbonyl)amino)methyl)phenyl)acetic acid
A solution of the compound obtained in the previous section, step a, (2.9 g, 17.57 mmol) in water (20 mL) and1,4-dioxane (20 mL) was stirred at room temperature and sodium hydroxide (0.702 g, 17.57 mmol) and Boc20(3.83 g, 17.57 mmol) were added simultaneously and allowed to stir at rt for 24 hours. The reaction mixture was25 concentrated and the crude compound was dissolved in water and acidified with saturated citric acid solution.The compound was precipitated; solid was filtered and washed with water and dried under vacuum to afford thetitle compound (2.5 g, 53%) as an off-white solid. Mass: 531.29 (2M+H).LC-MS (method 1): Rt = 0.23 min; m/z = 531.29 (2M+H+).

References:

ORYZON GENOMICS, S.A.;ORTEGA MUÑOZ, Alberto;SALAS SOLANA, Jorge;CARCELLER GONZÁLEZ, Elena WO2017/207813, 2017, A1 Location in patent:Page/Page column 131; 132

FullText

24424-99-5 Synthesis

24424-99-5
840 suppliers
$13.50/25G

42383-05-1 Synthesis