ChemicalBook CAS DataBase List 4-Bromo-1,2-(methylenedioxy)benzene

4-Bromo-1,2-(methylenedioxy)benzene synthesis

7synthesis methods

Product Name:4-Bromo-1,2-(methylenedioxy)benzene
CAS Number:2635-13-4
Molecular formula:C7H5BrO2
Molecular Weight:201.02

NBS (1.87 g, 10.50 mmol, 1.05 equiv.), HPLC-grade acetonitrile and benzo[d][1,3]dioxole (10 mmol) were placed into a flask and stirred until completely homogeneous. The solution was pumped through the Corning G1 photoreactor at the desired flow rate. The reaction mixture was collected from the reactor and combined with the two separate streams of toluene and water into a 10-mL Vapourtec static mixer coil; then, the mixture was pumped into a Zaiput liquid-liquid membrane separator, the organic phase was collected and passed twice more through the Zaiput membrane separator. The organic phase was evaporated under reduced pressure, providing the corresponding brominated product 4-Bromo-1,2-(methylenedioxy)benzene.

128-08-5 Synthesis

128-08-5
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274-09-9
459 suppliers
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2635-13-4
299 suppliers
$5.00/1g

Yield:2635-13-4 79%

Reaction Conditions:

in acetonitrile at 20; for 0.25 h;Flow reactor;UV-irradiation;

Steps:

General procedure for continuous-flow bromination

General procedure: NBS (1.87 g, 10.50 mmol, 1.05 equiv.), HPLC-grade acetonitrile, and the corresponding substrate (10 mmol) were placed into a flask and stirred until completely homogeneous. The solution was then pumped through the Corning G1 photoreactor at the desired flow rate. The reaction mixture was collected from the reactor and combined with the two separate streams of toluene and water into a 10-mL Vapourtec static mixer coil; then, the mixture was pumped into a Zaiput liquid-liquid membrane separator, the organic phase was collected and passed twice more through the Zaiput membrane separator. The organic phase was evaporated under reduced pressure, providing the corresponding brominated product.

References:

Waterford, Matthew;Saubern, Simon;Hornung, Christian H. [Australian Journal of Chemistry,2021,vol. 74,# 8,p. 569 - 573]

274-09-9
459 suppliers
$5.00/5g

2635-13-4
299 suppliers
$5.00/1g

References

Methanesulfonic acid, 1,1,1-trifluoro-, 1,3-benzodioxol-5-yl ester

109586-40-5
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2635-13-4
299 suppliers
$5.00/1g

References

274-09-9
459 suppliers
$5.00/5g

2635-13-4
299 suppliers
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5279-32-3 Synthesis

5279-32-3
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References

1-Oxaspiro[2.5]octa-5,7-dien-4-one, 7-bromo-

202001-83-0
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2635-13-4
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References

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