ChemicalBook CAS DataBase List 4-BROMO-1-BROMOMETHYL-2-CHLORO-BENZENE

4-BROMO-1-BROMOMETHYL-2-CHLORO-BENZENE synthesis

6synthesis methods

Product Name:4-BROMO-1-BROMOMETHYL-2-CHLORO-BENZENE
CAS Number:89720-77-4
Molecular formula:C7H5Br2Cl
Molecular Weight:284.38

89794-02-5 Synthesis

89794-02-5
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$6.00/1g

89720-77-4
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$40.52/1g

Yield: 80%

Reaction Conditions:

with N-Bromosuccinimide;dibenzoyl peroxide in tetrachloromethane for 18 h;Heating / reflux;

Steps:

17
To a solution of 2-Chloro 4-bromo toluene (5.0 g, 24.0 mmol) in carbon tetrachloride is added N-bromo succinimide (4.42 g, 24.8 mmol) and benzoyl peroxide (600 mg, 2.5 mmol) and the reaction is heated at reflux for 18 h. The reaction is allowed to cool to ambient temperature and is extracted saturated Na₂COs solution and brine (10 ml each). The organic layer is separated and concentrated in vacuo. The residue is purified by column chromatography eluting with 100% hexanes resulting in 4-Bromo- l-bromomethyl-2-chloro-benzene, as a colorless oil (5.5 g, 80%).

References:

NOVARTIS AG;NOVARTIS PHARMA GMBH WO2007/38459, 2007, A2 Location in patent:Page/Page column 73