4-bromo-1-ethyl-2-nitrobenzene synthesis

5synthesis methods

Product Name:4-bromo-1-ethyl-2-nitrobenzene
CAS Number:10342-66-2
Molecular formula:C8H8BrNO2
Molecular Weight:230.06

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Yield:10342-66-2 90%

Reaction Conditions:

with N-Bromosuccinimide in dichloromethane; for 2 h;Reflux;

Steps:

1 Synthesis of 2-ethyl-5-bromonitrobenzene

Add 1.1L of dichloromethane and 212g of o-ethylnitrobenzene (1.4mol) to a 3L reaction flask to heat up to reflux, and add 250g of N-bromosuccinimide (1.4mol) in batches under reflux for reflux reaction 2 hours. After the reaction is completed, the temperature is controlled at 25±5°C and 1.27kg of saturated sodium sulfite is added dropwise to the reaction system to terminate the reaction. Adding 0.72 kg of n-heptane to recrystallize to obtain 290.3 g of 2-ethyl-5-bromonitrobenzene with a molar yield of 90%.

References:

CN112538073,2021,A Location in patent:Paragraph 0157-0159

51529-96-5 Synthesis