4-Bromo-2,3',4',5'-tetrafluorobiphenyl synthesis
- Product Name:4-Bromo-2,3',4',5'-tetrafluorobiphenyl
- CAS Number:187804-77-9
- Molecular formula:C12H5BrF4
- Molecular Weight:305.07
105931-73-5
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Yield:187804-77-9 36.8 g
Reaction Conditions:
with tetrakis(triphenylphosphine) palladium(0);tetrabutylammomium bromide;potassium carbonate in toluene;butan-1-ol; for 6 h;Inert atmosphere;Reflux;
Steps:
15.1 First step
Into a reaction vessel under a nitrogen atmosphere, 50.0 g (166 mmol) of 4-bromo-2-fluoro-1-iodobenzene, 29.3 g (166 mmol) of (3,4,5-trifluorophenyl)boronic acid, 45.9 g (332 mmol) of potassium carbonate, 10.7 g (33.2 mmol) of tetrabutylammonium bromide (TBAB), 2.7 g (2.3 mmol) of tetrakis (triphenyl phosphine) palladium, 300 mL of toluene and 200 mL of 1-butanol were put, and the resultant mixture was subjected to heating reflux for 6 hours.
A reaction liquid was poured into 300 mL of water, and then the resultant mixture was extracted with toluene, and the resultant extract was washed with saturated brine, and dried over anhydrous magnesium sulfate.
Then, an insoluble matter was separated by filtration and then a filtrate was concentrated under reduced pressure.
A residue was purified according to fractionation by column chromatography using heptane as an eluent and silica gel as a filler, and thus 36.8 g of 4-bromo-2,3',4',5'-tetrafluoro-1,1'-biphenyl was obtained.
References:
EP2690103,2014,A1 Location in patent:Paragraph 0286
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143418-49-9
392 suppliers
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187804-77-9
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143418-49-9
392 suppliers
$5.00/1g
187804-77-9
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