![](/CAS/GIF/763132-62-3.gif)
4-BROMO-2-[(4-METHOXYANILINO)METHYL]BENZENOL synthesis
- Product Name:4-BROMO-2-[(4-METHOXYANILINO)METHYL]BENZENOL
- CAS Number:763132-62-3
- Molecular formula:C14H14BrNO2
- Molecular Weight:308.17
![Phenol,4-bromo-2-[[(4-methoxyphenyl)imino]methyl]-](/CAS/20180601/GIF/20772-73-0.gif)
20772-73-0
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![4-BROMO-2-[(4-METHOXYANILINO)METHYL]BENZENOL](/CAS/GIF/763132-62-3.gif)
763132-62-3
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Yield:763132-62-3 65%
Reaction Conditions:
with sodium tetrahydroborate in ethanol;Cooling with ice;Reflux;
Steps:
4.2. General method for synthesis of o-hydroxybenzylamines 1-16 and corresponding urea derivatives 17-32
General procedure: Anilines (4.0 mmol) in ethanol (10 mL) was treated with equimolar quantities of substituted salicylaldehydes. The mixture was refluxed for 4-6 h, and the reaction was monitored by TLC. The products thus precipitated were filtered and recrystallized in ethanol. Without further purification, to an ethanolic solution of synthesized Schiff bases, NaBH4 (4.0 mmol) was dissolved in ethanol and slowly added in an ice bath with stirring. The mixture was refluxed for 2-3 h. After that, the solvent was evaporated and water (15 mL) was added. The product extraction was carried out with CH2Cl2 (3 × 20 mL). The organic layer was dried over anhydrous Na2SO4 and concentrated. The residue was purified by recrystallization from ethanol to afford white or yellow crystals (1-16).
References:
Li, Zi-Lin;Li, Qing-Shan;Zhang, Hong-Jia;Hu, Yang;Zhu, Di-Di;Zhu, Hai-Liang [Bioorganic and Medicinal Chemistry,2011,vol. 19,# 15,p. 4413 - 4420] Location in patent:experimental part
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104-94-9
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$9.00/1g
![4-BROMO-2-[(4-METHOXYANILINO)METHYL]BENZENOL](/CAS/GIF/763132-62-3.gif)
763132-62-3
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![4-BROMO-2-[(4-METHOXYANILINO)METHYL]BENZENOL](/CAS/GIF/763132-62-3.gif)
763132-62-3
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106-41-2
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![4-BROMO-2-[(4-METHOXYANILINO)METHYL]BENZENOL](/CAS/GIF/763132-62-3.gif)
763132-62-3
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$10.00/25g
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106-41-2
478 suppliers
$13.00/5g
![p-Anisidine](/CAS/GIF/104-94-9.gif)
104-94-9
472 suppliers
$9.00/1g
![4-BROMO-2-[(4-METHOXYANILINO)METHYL]BENZENOL](/CAS/GIF/763132-62-3.gif)
763132-62-3
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