![](/CAS/GIF/156761-88-5.gif)
4-bromo-2-ethylpyridine synthesis
- Product Name:4-bromo-2-ethylpyridine
- CAS Number:156761-88-5
- Molecular formula:C7H8BrN
- Molecular Weight:186.05
![1-(4-bromopyridin-2-yl)ethanone](/CAS2/GIF/1060805-69-7.gif)
1060805-69-7
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$93.59/250mg
![4-bromo-2-ethylpyridine](/CAS/GIF/156761-88-5.gif)
156761-88-5
59 suppliers
$55.00/10mg
Yield:156761-88-5 91.4%
Reaction Conditions:
with aluminum (III) chloride;sodium tetrahydroborate in tetrahydrofuran at -5 - 65; for 12 h;Inert atmosphere;Temperature;
Steps:
1; 4-5; 1-2 Synthesis of 2-ethyl-4-bromopyridine
Add 50.0g (0.25mol, 1eq) of 1-(4-bromopyridin-2-yl)ethanone and 400g of tetrahydrofuran to a 1000ml four-necked reaction flask, start stirring, The reaction flask was replaced with nitrogen for protection, the temperature was reduced to -5°C, 14.2g (0.375mol, 1.5eq) of sodium borohydride and 66.7g (0.5mol, 2eq) of aluminum trichloride were added, After the addition, the temperature is slowly raised to 0°C and the reaction is stirred for 2h, and then heated to reflux (about 65°C) for 10h (detection of raw materials The solvent was removed under reduced pressure, and 300 g of water was slowly added dropwise to the residue under the protection of nitrogen, and the temperature was controlled not to exceed 35°C in an ice water bath. After dripping, it was stirred for 2h in an ice-water bath, extracted with chloroform 300g×2, combined the organic phases, and dissolved, the residue was 46.4g, recrystallized with ethanol 139.2g to obtain 42.5g of 2-ethyl-4-bromopyridine. The purity measured by HPLC was 98.4%, and the yield was 91.4%.
References:
CN112194620,2021,A Location in patent:Paragraph 0016; 0020; 0026-0027; 0029-0030
![Ethylmagnesium bromide](/CAS/GIF/925-90-6.gif)
925-90-6
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$12.00/5ml
![4-Bromopyridine hydrochloride](/CAS/GIF/19524-06-2.gif)
19524-06-2
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$6.00/5g
![4-bromo-2-ethylpyridine](/CAS/GIF/156761-88-5.gif)
156761-88-5
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$55.00/10mg
![2-ethyl-4-nitropyridine](/CAS/20150408/GIF/CB22712589.gif)
101860-96-2
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![4-bromo-2-ethylpyridine](/CAS/GIF/156761-88-5.gif)
156761-88-5
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![4-Amino-2-ethylpyridine](/CAS2/GIF/50826-64-7.gif)
50826-64-7
42 suppliers
$45.00/50mg
![4-bromo-2-ethylpyridine](/CAS/GIF/156761-88-5.gif)
156761-88-5
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$55.00/10mg
![2-ETHYL-PYRIDINE 1-OXIDE](/CAS/GIF/4833-24-3.gif)
4833-24-3
21 suppliers
$45.00/100mg
![4-bromo-2-ethylpyridine](/CAS/GIF/156761-88-5.gif)
156761-88-5
59 suppliers
$55.00/10mg