4-BROMO-2-FLUOROPHENYLISOTHIOCYANATE 96 synthesis
- Product Name:4-BROMO-2-FLUOROPHENYLISOTHIOCYANATE 96
- CAS Number:81171-71-3
- Molecular formula:C7H3BrFNS
- Molecular Weight:232.07
463-71-8
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367-24-8
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81171-71-3
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$25.00/1g
Yield:81171-71-3 98%
Reaction Conditions:
with sodium carbonate in chloroform at 20;
Steps:
4-Bromo-2-fluoro-1-isothiocyanatobenzene
Thiophosgene (66.5 mL, 86.8 mmol) was slowly added to a suspension of sodium carbonate (18.4 g, 17.4 mmol) and 4-bromo-2-fluoroaniline (15.0 g, 78.9 mmol) in CHCl3 (500 mL). The mixture was stirred overnight at RT, then filtered. The filtrate was concentrated to give product as a white solid (18.0 g, 98%). 1H NMR (400 MHz, CHLOROFORM-d) δ ppm 7.05 (t, J=8.22 Hz, 1 H) 7.22 - 7.28 (m, 1 H) 7.34 (dd, J=9.10, 2.05 Hz, 1 H).
References:
Frohn, Mike;Cee, Victor J.;Lanman, Brian A.;Pickrell, Alexander J.;Golden, Jennifer;Rivenzon-Segal, Dalia;Middleton, Scot;Fiorino, Mike;Xu, Han;Schrag, Michael;Xu, Yang;McElvain, Michele;Muller, Kristine;Siu, Jerry;Bürli, Roland [Bioorganic and Medicinal Chemistry Letters,2012,vol. 22,# 1,p. 628 - 633] Location in patent:supporting information; experimental part
75-15-0
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367-24-8
488 suppliers
$15.00/25g
81171-71-3
17 suppliers
$25.00/1g
367-24-8
488 suppliers
$15.00/25g
81171-71-3
17 suppliers
$25.00/1g