4-broMo-2-isopropoxyphenol synthesis

Yield:916228-69-8 94%

Reaction Conditions:

with pyridinium hydrobromide perbromide in dichloromethane at 20; for 6 h;

Steps:

1 The intermediate 4-Bromo-2-isopropoxy-phenol was prepared as follows:

To a suspension of pyridinium tribromide (116g, 0.362 mol) in 250 ml dichloromethane, was added 2- isopropoxyphenol (50 g, 0.329 mol) in 150 ml dichloromethane. The mixture was stirred at room temperature for 6 hrs. The reaction mixture was quenched with aqueous HCI (1N, 200ml). After separation, the organic phase was washed with saturated sodium thiosulfate (150 ml), and brine (150 ml), and dried over anhydrous magnesium sulfate. After filtering off magnesium sulfate, the filtrate was evaporated to give 71g 4-Bromo-2-isopropoxy-phenol (94% yield).

References:

WO2013/16720,2013,A2 Location in patent:Page/Page column 40-41