4-broMo-2-isopropyl-6-Methylaniline synthesis
- Product Name:4-broMo-2-isopropyl-6-Methylaniline
- CAS Number:773887-07-3
- Molecular formula:C10H14BrN
- Molecular Weight:228.13
5266-85-3
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Yield:773887-07-3 85%
Reaction Conditions:
with 1-bromopyrrolidine-2,5-dione in N,N-dimethyl-formamide at 0 - 20;
Steps:
2-Isopropyl-6-methyl-4-(l-methyl-lH-pyrazol-4-yl)aniline
To 2-isopropyl-6-methylaniline [773887-07-3] (1 g, 6.701 mmol) in DMF(dry) (16 mL) at 0° was added NBS (1.30 g, 7.4 mmol). The reaction mixture was then allowed to warm to RT and stirred overnight. Water was then added to the r.m. and it was extracted with DCM. The organic layer was dried over MgS04 and coevaporated with MIK. The crude was then purified with using pure heptane to 20% of EtOAc as eluent. All product fractions were pooled and evaporated to give 4-bromo-2-isopropyl-6-methylaniline (1.30 g, yield 85%).
References:
WO2021/123294,2021,A1 Location in patent:Page/Page column 47
52414-97-8
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