![](/CAS/GIF/103966-66-1.gif)
4-bromo-2-methoxy-1-nitrobenzene synthesis
- Product Name:4-bromo-2-methoxy-1-nitrobenzene
- CAS Number:103966-66-1
- Molecular formula:C7H6BrNO3
- Molecular Weight:232.03
![Methanol](/CAS/GIF/67-56-1.gif)
67-56-1
739 suppliers
$7.29/5ml-f
![2-Fluoro-4-bromonitrobenzene](/CAS/GIF/321-23-3.gif)
321-23-3
255 suppliers
$10.00/1g
![Sodium Methoxide](/CAS/GIF/124-41-4.gif)
124-41-4
682 suppliers
$12.00/25g
![4-bromo-2-methoxy-1-nitrobenzene](/CAS/GIF/103966-66-1.gif)
103966-66-1
125 suppliers
$7.00/100mg
Yield: 100%
Reaction Conditions:
at 60; for 3 h;Temperature;
Steps:
1.1; 2.1; 3.1 (1) Synthesis of compound III
Add 220g (1mol) of 4-bromo-2-fluoro-1-nitrotoluene, 1000ml of methanol to the reaction flask, add 108g (2mol) of sodium methoxide to 60°C, keep the temperature for 3 hours, and HPLC track the reaction until 4 The reaction of bromo-2-fluoro-1-nitrotoluene is complete; the reaction solution is concentrated, 1000 ml of water is added, and 1000 ml of ethyl acetate are added for layering, and the organic phase is concentrated to obtain 232 g of compound III. The molar yield: 100%.
References:
CN112300028, 2021, A Location in patent:Paragraph 0032; 0034-0035; 0052; 0054-0055; 0070; 0072-0073
![2-Fluoro-4-bromonitrobenzene](/CAS/GIF/321-23-3.gif)
321-23-3
255 suppliers
$10.00/1g
![Sodium Methoxide](/CAS/GIF/124-41-4.gif)
124-41-4
682 suppliers
$12.00/25g
![4-bromo-2-methoxy-1-nitrobenzene](/CAS/GIF/103966-66-1.gif)
103966-66-1
125 suppliers
$7.00/100mg
![3-Bromoanisole](/CAS/GIF/2398-37-0.gif)
2398-37-0
576 suppliers
$8.00/10g
![3-BROMO-4-NITROANISOLE](/CAS/GIF/98447-30-4.gif)
98447-30-4
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$10.00/100mg
![1-BroMo-5-Methoxy-2,4-dinitro-benzene](/CAS/GIF/181995-71-1.gif)
181995-71-1
6 suppliers
inquiry
![4-bromo-2-methoxy-1-nitrobenzene](/CAS/GIF/103966-66-1.gif)
103966-66-1
125 suppliers
$7.00/100mg
![Methanol](/CAS/GIF/67-56-1.gif)
67-56-1
739 suppliers
$7.29/5ml-f
![2-Fluoro-4-bromonitrobenzene](/CAS/GIF/321-23-3.gif)
321-23-3
255 suppliers
$10.00/1g
![4-bromo-2-methoxy-1-nitrobenzene](/CAS/GIF/103966-66-1.gif)
103966-66-1
125 suppliers
$7.00/100mg
![3-Bromoanisole](/CAS/GIF/2398-37-0.gif)
2398-37-0
576 suppliers
$8.00/10g
![3-BROMO-4-NITROANISOLE](/CAS/GIF/98447-30-4.gif)
98447-30-4
81 suppliers
$10.00/100mg
![4-bromo-2-methoxy-1-nitrobenzene](/CAS/GIF/103966-66-1.gif)
103966-66-1
125 suppliers
$7.00/100mg