ChemicalBook CAS DataBase List 4-bromo-2-methoxy-1-nitrobenzene

4-bromo-2-methoxy-1-nitrobenzene synthesis

6synthesis methods

Product Name:4-bromo-2-methoxy-1-nitrobenzene
CAS Number:103966-66-1
Molecular formula:C7H6BrNO3
Molecular Weight:232.03

67-56-1 Synthesis

67-56-1
746 suppliers
$7.29/5ml-f

321-23-3
255 suppliers
$10.00/1g

124-41-4 Synthesis

124-41-4
692 suppliers
$12.00/25g

103966-66-1
123 suppliers
$7.00/100mg

Yield: 100%

Reaction Conditions:

at 60; for 3 h;Temperature;

Steps:

1.1; 2.1; 3.1 (1) Synthesis of compound III
Add 220g (1mol) of 4-bromo-2-fluoro-1-nitrotoluene, 1000ml of methanol to the reaction flask, add 108g (2mol) of sodium methoxide to 60°C, keep the temperature for 3 hours, and HPLC track the reaction until 4 The reaction of bromo-2-fluoro-1-nitrotoluene is complete; the reaction solution is concentrated, 1000 ml of water is added, and 1000 ml of ethyl acetate are added for layering, and the organic phase is concentrated to obtain 232 g of compound III. The molar yield: 100%.

References:

CN112300028, 2021, A Location in patent:Paragraph 0032; 0034-0035; 0052; 0054-0055; 0070; 0072-0073

321-23-3
255 suppliers
$10.00/1g

124-41-4 Synthesis

124-41-4
692 suppliers
$12.00/25g

103966-66-1
123 suppliers
$7.00/100mg

References

2398-37-0 Synthesis