ChemicalBook CAS DataBase List 4-Bromo-2-methyl-1H-pyrrolo[2,3-b]pyridine

4-Bromo-2-methyl-1H-pyrrolo[2,3-b]pyridine synthesis

5synthesis methods

Product Name:4-Bromo-2-methyl-1H-pyrrolo[2,3-b]pyridine
CAS Number:1014613-64-9
Molecular formula:C8H7BrN2
Molecular Weight:211.06

4-Bromo-2-methyl-1-phenylsulfonyl-7-azaindole

1014613-05-8
46 suppliers
$200.00/50mg

4-Bromo-2-methyl-1H-pyrrolo[2,3-b]pyridine

1014613-64-9
66 suppliers
$45.00/100mg

Yield: 100%

Reaction Conditions:

with hydrogenchloride;water in 1,4-dioxane at 60; for 16 h;Inert atmosphere;

Steps:

10
Description 10 4-bromo-2-methyl-1W-pyrrolo[2,3-b]pyridine To a solution of 4-bromo-2-methyl-1 -(phenylsulfonyl)-1 H-pyrrolo[2,3-5]pyridine (D9) (16 g, 0.045 mol) in 1 ,4 dioxane (320 mL) was added 2M aqueous sodium hydroxide (114 rmL, 0.228 mol).The reaction was heated to 6O⁰C for 16 h. The reaction was cooled to ambient temperature. The organic layer was separated and the aqueous extracted with ethylacetate. The combined organics were washed with brine and dried over magnesium sulphate, filtered and concentrated in vacuo to give the title compound as a cream solid (10.07 g, 104%) LC/MS (Method B): MH⁺ 21 1/213 seen at retention time 1.04 mins.

References:

GLAXO GROUP LIMITED WO2009/112475, 2009, A1 Location in patent:Page/Page column 62