![](/CAS/GIF/35979-69-2.gif)
4-BroMo-2-Methylbutan-2-ol synthesis
- Product Name:4-BroMo-2-Methylbutan-2-ol
- CAS Number:35979-69-2
- Molecular formula:C5H11BrO
- Molecular Weight:167.04
![Ethyl 3-bromopropionate](/CAS/GIF/539-74-2.gif)
539-74-2
276 suppliers
$5.00/5g
![Methylmagnesium Bromide](/CAS/GIF/75-16-1.gif)
75-16-1
263 suppliers
$12.00/10ml
![4-BroMo-2-Methylbutan-2-ol](/CAS/GIF/35979-69-2.gif)
35979-69-2
69 suppliers
$50.00/50 mg
Yield: 75.1%
Reaction Conditions:
in tetrahydrofuran at 0;
Steps:
45 Intermediate 45 4-bromo-2-methylbutan-2-ol
Intermediate 45 4-bromo-2-methylbutan-2-ol To a solution of methyl 3-bromopropanoate (0.2 g, 1.2 mmol,) in THF (5 mL) was added methyl magnesium bromide (2.4 mL, 2.4 mmol) at 0 °C. The mixture was stirred at this temperature until the substrate was consumed based on tic [petroleum ether/ethyl acetate (3: 1); product Rf 0.3]. The reaction was quenched with ammonium chloride (2 mL) at 0 °C. The mixture was partitioned between ethyl acetate and water. The combined organic layer was dried over sodium sulfate, filtered and concentrated, to give a crude product which was purified by a column chromatography eluting with petroleum ether/ ethyl acetate (3: 1 ) to give 4-bromo-2- methylbutan-2-ol (0.15 g, 75.1 % yield) as a yellow oil.
References:
HYDRA BIOSCIENCES, INC.;CHENARD, Bertrand;GALLASCHUN, Randall WO2014/143799, 2014, A2 Location in patent:Page/Page column 403
![3-hydroxy-3-methylbutyl 4-methylbenzenesulfonate](/CAS/GIF/17689-66-6.gif)
17689-66-6
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$547.00/5g
![4-BroMo-2-Methylbutan-2-ol](/CAS/GIF/35979-69-2.gif)
35979-69-2
69 suppliers
$50.00/50 mg
![Methyl 3-bromopropionate](/CAS/GIF/3395-91-3.gif)
3395-91-3
267 suppliers
$5.00/5g
![Methylmagnesium Bromide](/CAS/GIF/75-16-1.gif)
75-16-1
263 suppliers
$12.00/10ml
![4-BroMo-2-Methylbutan-2-ol](/CAS/GIF/35979-69-2.gif)
35979-69-2
69 suppliers
$50.00/50 mg
![Ethyl 3-bromopropionate](/CAS/GIF/539-74-2.gif)
539-74-2
276 suppliers
$5.00/5g
![4-BroMo-2-Methylbutan-2-ol](/CAS/GIF/35979-69-2.gif)
35979-69-2
69 suppliers
$50.00/50 mg
![Silane, (3-bromo-1,1-dimethylpropoxy)trimethyl-](/CAS/GIF/67883-17-4.gif)
67883-17-4
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inquiry
![4-BroMo-2-Methylbutan-2-ol](/CAS/GIF/35979-69-2.gif)
35979-69-2
69 suppliers
$50.00/50 mg