4-BROMO-2-METHYLTHIAZOLE synthesis
- Product Name:4-BROMO-2-METHYLTHIAZOLE
- CAS Number:298694-30-1
- Molecular formula:C4H4BrNS
- Molecular Weight:178.05
616-42-2
191 suppliers
$12.00/5g
298694-30-1
106 suppliers
$16.00/100mg
Yield:298694-30-1 55%
Reaction Conditions:
Stage #1:2,4-dibromo-1,3-thiazole with n-butyllithium in tetrahydrofuran;hexanes at -78; for 1 h;
Stage #2:dimethylsulfite in tetrahydrofuran;hexanes at -78 - 20;
Steps:
52
Example 52; 4-Bromo-2-methyl-thiazole (142); 2,4-Dibromothiazole (2.4 g, 9.8 mmol) was dissolved in abs. THF (50 ml) and the resulting solution was stirred under argon at -78 °C. A solution of BuLi (4.2 ml, 6 mmol, 2.5 M in hexanes) was added and the stirring was continued for Ih whereafter a solution of dimethylsulfate (2.7 ml) in THF (5 ml) was added dropwise. After stirring for 4h at -78 °C, the reaction mixture was warmed to room temperature and stirred EPO
References:
TIBOTEC PHARMACEUTICALS LTD.;MEDIVIR AB WO2007/14922, 2007, A1 Location in patent:Page/Page column 121-122
4175-77-3
316 suppliers
$6.00/1g
77-78-1
292 suppliers
$19.69/1ml
298694-30-1
106 suppliers
$16.00/100mg
333-27-7
299 suppliers
$12.00/1g
298694-30-1
106 suppliers
$16.00/100mg