4-BROMO-3',4'-DIFLUOROBENZOPHENONE synthesis
- Product Name:4-BROMO-3',4'-DIFLUOROBENZOPHENONE
- CAS Number:844878-99-5
- Molecular formula:C13H7BrF2O
- Molecular Weight:297.09
1272202-25-1
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844878-99-5
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Yield:844878-99-5 140 mg
Reaction Conditions:
with 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione in tetrahydrofuran at 60;
Steps:
4.3.1. Method B
General procedure: To a mixture of alcohol (1 equiv) in dry THF was added 2-iodoxybenzoic acid (2 equiv). The reaction mixture was stirred at 60 °C overnight, cooled to room temperature and quenched with Na2S2O3. The aqueous layer was extracted with ethyl acetate and the organic layer was washed with water, neutralised with 0.5N NaOH and dried over sodium sulfate, filtered and concentrated to dryness. The product was purified by column chromatography or by recrystallisation.
References:
Wetzel, Marie;Gargano, Emanuele M.;Hinsberger, Stefan;Marchais-Oberwinkler, Sandrine;Hartmann, Rolf W. [European Journal of Medicinal Chemistry,2012,vol. 47,# 1,p. 1 - 17] Location in patent:experimental part
589-87-7
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188345-25-7
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844878-99-5
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348-61-8
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844878-99-5
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1122-91-4
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844878-99-5
23 suppliers
$294.00/1g