4-Bromo-3,5-dichloro-benzoic acid methyl ester synthesis
- Product Name:4-Bromo-3,5-dichloro-benzoic acid methyl ester
- CAS Number:117738-81-5
- Molecular formula:C8H5BrCl2O2
- Molecular Weight:283.93
41727-48-4
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Yield:-
Reaction Conditions:
with copper(I) bromide;sodium nitrite in hydrogen bromide;
Steps:
ii 4-Bromo-3,5-dichlorobenzaldehyde
ii) Methyl 4-amino-3,5-dichlorobenzoate (32 g.) dissolved in 48% hydrobromic acid (100 ml.) was cooled to 0° and sodium nitrite (10.5 g.) was added. The solution was added slowly to a mixture of 48% hydrobromic acid (80 ml.) and cuprous bromide (35 g.) and the mixture heated at reflux for 2 hours. After cooling, the mixture was extracted with ethyl acetate and the organic extracts washed with brine, dried (anhydrous magnesium sulphate) and evaporated to give a dark solid. Crystallisation from ethyl acetate gave methyl 4-bromo-3,5-dichlorobenzoate (20 g.).
References:
US5502073,1996,A
56961-25-2
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