ChemicalBook CAS DataBase List 4-bromo-3-formylbenzoic acid

4-bromo-3-formylbenzoic acid synthesis

8synthesis methods

Product Name:4-bromo-3-formylbenzoic acid
CAS Number:776315-23-2
Molecular formula:C8H5BrO3
Molecular Weight:229.03

858124-35-3
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$22.00/100mg

776315-23-2
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$160.00/250mg

Yield: 100%

Reaction Conditions:

with water;lithium hydroxide in tetrahydrofuran at 20; for 2 h;

Steps:

49.A Step C: 4-bromo-3-(2-carboxyethyl)benzoic acid
General procedure: Lithium hydroxide (111.7 mg; 4.66 mmol; 3.00 eq.) was added to a solution of methyl 4-bromo-3-(3-ethoxy-3-oxo-propyl)benzoate (490.0 mg; 1.55 mmol; 1.00 eq.) in THF (12 mL) and water (4 mL).
The reaction was then stirred 2h at rt then THF was evaporated and the residue was diluted with water.
The pH was adjusted to 1 with 1N HCl and the precipitate obtained was filtered, washed with water and dried under vacuum to give 4-bromo-3-(2-carboxyethyl)benzoic acid (374.7 mg; 71%) as a white solid.

References:

Inventiva;BARTH, Martine;CONTAL, Sylvie;JUNIEN, Jean-Louis;MASSARDIER, Christine;MONTALBETTI, Christian;SOUDE, Anne EP3632908, 2020, A1 Location in patent:Paragraph 0180; 0182; 0196

201230-82-2 Synthesis