4-Bromo-3-methoxy-2-methylbenzoicacid synthesis

2synthesis methods

Product Name:4-Bromo-3-methoxy-2-methylbenzoicacid
CAS Number:1154060-65-7
Molecular formula:C9H9BrO3
Molecular Weight:245.07

methyl 4-bromo-3-methoxy-2-methylbenzoate

1149388-20-4
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1154060-65-7
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Yield:1154060-65-7 94%

Reaction Conditions:

Stage #1: 4-bromo-3-methoxy-2-methylbenzoic acid methyl esterwith sodium hydroxide;water at 100; for 1 h;
Stage #2: with hydrogenchloride in water at 20;

Steps:

68.b

Methyl 4-bromo-3-methoxy-2-methylbenzoate (1.3 g, 5.02 mmol) was dissolved in 15% sodium hydroxide (20 mL) and heated at 100° C. for 1 hour. The mixture was allowed to cool to room temperature, acidified using hydrochloric acid (4 M) and was extracted with dichloromethane. The combined organic phases were dried over magnesium sulfate and concentrated in vacuo to give 1.15 g (94% yield) of the title compound:MS (ESI) m/z 245, 243 [M-1]^-

References:

US2009/131468,2009,A1 Location in patent:Page/Page column 41

4-Bromo-3-hydroxy-2-methyl-benzoic acid methyl ester

1149388-19-1
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$340.00/1g

1154060-65-7
9 suppliers
$1189.00/500mg

References