![](/CAS/GIF/19056-40-7.gif)
4-BROMO-3-METHOXYANILINE synthesis
- Product Name:4-BROMO-3-METHOXYANILINE
- CAS Number:19056-40-7
- Molecular formula:C7H8BrNO
- Molecular Weight:202.05
![2-BROMO-5-NITROANISOLE](/CAS/GIF/77337-82-7.gif)
77337-82-7
175 suppliers
$8.00/1g
![4-BROMO-3-METHOXYANILINE](/CAS/GIF/19056-40-7.gif)
19056-40-7
209 suppliers
$10.00/1g
Yield:19056-40-7 89%
Reaction Conditions:
aluminum nickel in methanol;hexane;ethyl acetate
Steps:
1 5-(4-Bromo-3-methoxyphenyl)-N-hydroxy-2-furancarboximidamide Hydrochloride STR4
EXAMPLE 1 5-(4-Bromo-3-methoxyphenyl)-N-hydroxy-2-furancarboximidamide Hydrochloride STR4 2-Bromo-5-nitroanisole (25 g, 0.116 mole) (Fairfield Chemical Co., Blythewood, S.C.) was dissolved in 150 ml of 70:30 methanol/ethyl acetate. Raney nickel (1.0 g) was added to the solution. The mixture was hydrogenated on a Parr shaker for 3 hours, then filtered through Celite. The dark brown filtrate was treated with Darco and concentrated under reduced pressure to a brown solid. The solid was dissolved in 50:50 ethyl acetate/hexane (1 L) and filtered through a 2-inch cake of silica gel (column grade). The resulting solution was concentrated under reduced pressure to a solid yielding 19.3 g (89% yield) of 4-bromo-3-anisidine (O).
References:
Norwich Eaton Pharmaceuticals, Inc. US4882354, 1989, A
![m-Anisidine](/CAS/GIF/536-90-3.gif)
536-90-3
290 suppliers
$10.00/5g
![4-BROMO-3-METHOXYANILINE](/CAS/GIF/19056-40-7.gif)
19056-40-7
209 suppliers
$10.00/1g
![m-Anisidine](/CAS/GIF/536-90-3.gif)
536-90-3
290 suppliers
$10.00/5g
![2-BROMO-5-METHOXYANILINE](/CAS/GIF/59557-92-5.gif)
59557-92-5
175 suppliers
$6.00/1g
![4-BROMO-3-METHOXYANILINE](/CAS/GIF/19056-40-7.gif)
19056-40-7
209 suppliers
$10.00/1g
![2,4-dibromo-5-methoxyaniline](/CAS/20180629/GIF/35736-52-8.gif)
35736-52-8
44 suppliers
$17.00/250mg
![2-Bromoanisole](/CAS/GIF/578-57-4.gif)
578-57-4
306 suppliers
$6.00/10g
![Iron](/CAS/GIF/7439-89-6.gif)
7439-89-6
423 suppliers
$10.00/25g
![4-BROMO-3-METHOXYANILINE](/CAS/GIF/19056-40-7.gif)
19056-40-7
209 suppliers
$10.00/1g
![(4-Bromo-3-methoxy-phenyl)-carbamic acid tert-butyl ester](/CAS/20180629/GIF/262433-28-3.gif)
262433-28-3
4 suppliers
inquiry
![4-BROMO-3-METHOXYANILINE](/CAS/GIF/19056-40-7.gif)
19056-40-7
209 suppliers
$10.00/1g