ChemicalBook CAS DataBase List 4-BroMo-4'-Methylbiphenyl

4-BroMo-4'-Methylbiphenyl synthesis

4synthesis methods

Product Name:4-BroMo-4'-Methylbiphenyl
CAS Number:844856-52-6
Molecular formula:C13H11Br
Molecular Weight:247.13

108-36-1
453 suppliers
$10.00/1g

5720-05-8
436 suppliers
$5.00/1g

844856-52-6
32 suppliers
$481.00/1g

19399-68-9
4 suppliers
inquiry

Yield:844856-52-6 27% ，19399-68-9 68%

Reaction Conditions:

with disodium[(N,N’-bis(2-hydroxy-5-sulfonatobenzyl)-1,2-diphenyl-1,2-diaminoethano)palladate(II)];caesium carbonate in water at 80; for 1 h;Suzuki-Miyaura Coupling;

Steps:

Catalysis experiments and gas chromatographic analysis of the reaction mixtures

General procedure: Stock solutions of the catalysts (Na2[Pd(HSS)], Na2[Pd(PrHSS)], Na2[Pd(BuHSS)],Na2[Pd(dPhHSS)], rac-Na2[Pd(CyHSS)], Na2[Pd(cis-CyHSS)]) Na2[Pd(trans-CyHSS)]) were prepared by dissolving 5.0×10-7 mol complex in 6 mL water. In general, 0.5 mmol aryl-halide, 0.75 mmol boronic acid derivative (1.5 mmol in the reactions of aryl-dihalides), and 0.5 mmolbase (Cs2CO3) were used in each reaction. Good quality distilled water was used as solvent, the organic phase was comprised of the substrates. 3 mL of water was used in each reaction. The reactions were carried out at 80 °C in 30-120 min reaction time. At the end of the reactions, the mixtures were allowed to cool to room temperature and then were extracted by chlorofom (2 mL). After separation of the phases (15-20 min) the organic phase was removed by a Pasteur pipette and filtered through a short MgSO4 plug.

References:

Bunda, Szilvia;Joó, Ferenc;Kathó, ágnes;Udvardy, Antal;Voronova, Krisztina [Molecules,2020,vol. 25,# 17] Location in patent:supporting information

591-18-4 Synthesis