4-BROMO-5-FLUORO-2-METHYLANILINE synthesis
- Product Name:4-BROMO-5-FLUORO-2-METHYLANILINE
- CAS Number:52723-82-7
- Molecular formula:C7H7BrFN
- Molecular Weight:204.04
367-29-3
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52723-82-7
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Yield: 71%
Reaction Conditions:
with N-Bromosuccinimide in N,N-dimethyl-formamide at 25; for 12 h;
Steps:
4-Bromo-5-fluoro-2-methylaniline
A mixture of NBS (14.22 g, 80 mmol), 5-fluoro-2-methylaniline (10 g, 80 mmol) and N,Ndimethylformamide (200 mL) was stirred at 2500 for 12 h. The mixture was then poured into water and the solid was filtered to afford the title compound (13 g, 71 % yield) as yellow solid. L0-MS m/z 204 (M+H), 1 .68 mm (ret. time).
References:
GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED;ASTEX THERAPEUTICS LIMITED;KERNS, Jeffrey K.;YAN, Hongxing;CALLAHAN, James Francis;HEIGHTMAN, Thomas Daniel;BOEHM, Jeffrey Charles;WOOLFORD, Alison Jo-Anne WO2016/203401, 2016, A1 Location in patent:Page/Page column 72
948294-26-6
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52723-82-7
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452-62-0
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52723-82-7
127 suppliers
$7.00/1g