4-BROMO-5-METHYL-2-THIOPHENECARBOXYLIC ACID synthesis
- Product Name:4-BROMO-5-METHYL-2-THIOPHENECARBOXYLIC ACID
- CAS Number:29421-99-6
- Molecular formula:C6H5BrO2S
- Molecular Weight:221.07
1918-79-2
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29421-99-6
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Yield:29421-99-6 100%
Reaction Conditions:
with iron(III) chloride;bromine in acetic acid at 25; for 5 h;
Steps:
9
A solution of bromine (725 uL, 14.1 mmol) in AcOH (2.8 ml.) was added dropwise to δ-methyl^-thiophenecarboxylic acid (2 g, 14.1 mmol) and FeCI3 (456 mg, 2.81 mmol) in AcOH (28 ml.) at 25 0C. After 5h, the solution was poured onto ice and the precipitate was filtered and washed with water affording the title compound (3 g, quant.) as a yellow powder: LCMS (ES) m/z 222 (M+H)+.
References:
WO2008/98104,2008,A1 Location in patent:Page/Page column 81
29421-73-6
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29421-99-6
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$60.00/10mg
124-38-9
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$214.00/14L
29421-99-6
60 suppliers
$60.00/10mg
29421-73-6
89 suppliers
$19.00/1g
124-38-9
121 suppliers
$214.00/14L
29421-99-6
60 suppliers
$60.00/10mg
1256286-44-8
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29421-99-6
60 suppliers
$60.00/10mg