4-broMo-5-Methylpicolinaldehyde synthesis

Yield:1196157-14-8 10.1 g

Reaction Conditions:

with manganese(IV) oxide in dichloromethane at 20;

Steps:

1-2

(6) Add 12g of compound F, 72g of manganese dioxide, and 250mL of dichloromethane to the reaction flask, stir overnight at room temperature, TLC detects the reaction is complete, filtered, and the filtrate was spin-dried to obtain a dark gray solid, which was purified by column to obtain 10.1g of yellow The solid, namely compound G, has a purity of 98.2%;

References:

CN113563258,2021,A Location in patent:Paragraph 0018-0019