4-BroMo-6,7-diMethoxyquinazoline synthesis
- Product Name:4-BroMo-6,7-diMethoxyquinazoline
- CAS Number:1260640-98-9
- Molecular formula:C10H9BrN2O2
- Molecular Weight:269.09
13794-72-4
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Yield:1260640-98-9 90.35%
Reaction Conditions:
with carbon tetrabromide;triphenylphosphine in dichloromethane at 0 - 20; for 2 h;
Steps:
4-6 Example 4: Synthesis of Compound 4
50mmol compound 5,62.5mmol carbon tetrabromide dissolved in 100mL dichloromethane,Cool to 0 , add 67.5mmol triphenylphosphine under stirring,Stir at room temperature for 2h,Concentrate under reduced pressure to obtain an oil, which is quickly added to n-hexane,A white precipitate was obtained, filtered and concentrated,12.173g of compound 4 was obtained with a yield of 90.35% and a purity of 99.86%.
References:
CN110894189,2020,A Location in patent:Paragraph 0023; 0042-0047
13794-72-4
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1260640-98-9
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5653-40-7
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