4-bromo-N-isobutylbenzenesulfonamide synthesis
- Product Name:4-bromo-N-isobutylbenzenesulfonamide
- CAS Number:7510-83-0
- Molecular formula:C10H14BrNO2S
- Molecular Weight:292.19
78-81-9
189 suppliers
$19.60/250ml
98-58-8
247 suppliers
$12.00/5g
7510-83-0
7 suppliers
$600.00/10g
Yield:7510-83-0 78%
Reaction Conditions:
with pyridine in dichloromethane at 20; for 16 h;
Steps:
2.1 Step 1: 4-Bromo-N-isobutylbenzenesulfonamide
To a solution of 4-bromobenzenesulfonyl chloride (2 g, 7.8 mmol) in DCM (40 mL) was added pyridine (1.9 mL, 23.5 mmol) followed by isobutylamine (1.56 mL, 15.7 mmol) and the reaction was stirred at room temperature for 16 hours. 1M aqueous HCl was added and the reaction extracted with DCM, filtered through a phase separator and concentrated to give 4-bromo-N-isobutyl-benzenesulfonamide (1.99 g). LCMS (m/z, Method A) ES+ 294[M+1]+
References:
US2014/163024,2014,A1 Location in patent:Paragraph 0437