(4-BROMO-PHENOXY)-ACETIC ACID HYDRAZIDE synthesis

6synthesis methods

Product Name:(4-BROMO-PHENOXY)-ACETIC ACID HYDRAZIDE
CAS Number:16738-00-4
Molecular formula:C8H9BrN2O2
Molecular Weight:245.07

6964-29-0 Synthesis

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Yield:16738-00-4 93%

Reaction Conditions:

with hydrazine hydrate monohydrate in ethanol;Reflux;

Steps:

4.3.2. General procedure for the synthesis of hydrazides from corresponding esters (Procedure A)

General procedure: Ester (1 eq) and N₂H₂.H₂O (5 eq) were solubilized in EtOH (5 mL/mmol). The resulting mixture was refluxed 18-24 h. The reaction was monitored by TLC (CH₂Cl₂/MeOH, 95/5) and LCMS. Solvents were removed under reduced pressure and crude products were extracted with CH₂Cl₂ or ethyl acetate. The combined organics werewashed with saturated Na₂CO₃ aqueous solution, and dried (Na₂SO₄) and concentrated under reduced pressure to give the desired hydrazide.

References:

Maingot, Lucie;Elbakali, Jamal;Dumont, Julie;Bosc, Damien;Cousaert, Nicolas;Urban, Agathe;Deglane, Gaelle;Villoutreix, Bruno;Nagase, Hideaki;Sperandio, Olivier;Leroux, Florence;Deprez, Benoit;Deprez-Poulain, Rebecca [European Journal of Medicinal Chemistry,2013,vol. 69,p. 244 - 261]

1878-91-7 Synthesis