ChemicalBook CAS DataBase List 4-BROMOBENZENESULFONIC ACID MONOHYDRATE

4-BROMOBENZENESULFONIC ACID MONOHYDRATE synthesis

11synthesis methods

Product Name:4-BROMOBENZENESULFONIC ACID MONOHYDRATE
CAS Number:138-36-3
Molecular formula:C6H5BrO3S
Molecular Weight:237.07

108-86-1 Synthesis

108-86-1
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138-36-3
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Yield: 85%

Reaction Conditions:

with 1,3-disulfonic acid imidazolonium chloride in water at 50; for 0.116667 h;Green chemistry;regioselective reaction;

Steps:

general sulfonation procedure (table 1)
General procedure: To a round-bottomed flask (10 mL) containing of 1,3-disulfonic acid imidazolium chloride ([Dsim]Cl) (2 mmol, 0.513 g) were added water (2 mmol, 0.036 g) and the aromatic substrate (2mmol). The reaction mixture was stirred at 50 °C for the requisite time. After the reaction was complete (monitored withTLC), CH2Cl2 (10 mL) was added and the reaction mixture stirred for 2 min. The organic solvent was removed, and the product was purified by short column chromatography.

References:

Moosavi-Zare, Ahmad Reza;Zolfigol, Mohammad Ali;Noroozizadeh, Ehsan [Synlett,2016,vol. 27,# 11,art. no. ST-2015-D0890-L,p. 1682 - 1684]