4'-(BROMOMETHYL)-[1,1'-BIPHENYL]-4-CARBONITRILE synthesis
- Product Name:4'-(BROMOMETHYL)-[1,1'-BIPHENYL]-4-CARBONITRILE
- CAS Number:50670-51-4
- Molecular formula:C14H10BrN
- Molecular Weight:272.14
154493-59-1
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50670-51-4
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Yield:50670-51-4 92.82%
Reaction Conditions:
with phosphorus tribromide in dichloromethane at 0 - 20;
Steps:
38
Intermediate 38: 4'-(bromomethyl)-4-biphenvlcarbonitrile; To a solution of 4'-(hydroxymethyl)-4-biphenylcarbonitrile (Intermediate 36, 1.49 g, 7.2 mmol) in CH2CI2 (4OmL) cooled in a ice bath, was added dropwise PBr3 (solution 1 M/CH2CI2, 3.56 ml_, 0.5 equiv.). The mixture was stirred at 00C for 30 minutes, then at room temperature for 1 hour and then poured into water. After extraction with CH2CI2, the organic phase was dried over sodium sulfate and concentrated under reduced pressure. The title compound was obtained as a cream solid (1.8 g, yield: 92.82%). LC/MS: (M+H)= 273, Rt= 3.53min
References:
WO2010/15652,2010,A2 Location in patent:Page/Page column 47
50670-50-3
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50670-51-4
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623-00-7
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$6.00/10g
50670-51-4
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5720-05-8
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$5.00/1g
50670-51-4
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