![](/CAS/20180601/GIF/1192352-33-2.gif)
4-(BROMOMETHYL)ISOQUINOLINE HBR synthesis
- Product Name:4-(BROMOMETHYL)ISOQUINOLINE HBR
- CAS Number:1192352-33-2
- Molecular formula:C10H9Br2N
- Molecular Weight:302.9932
![(isoquinolin-4-yl)methanol](/CAS/20180713/GIF/73048-60-9.gif)
73048-60-9
22 suppliers
$265.00/100mg
![4-(BROMOMETHYL)ISOQUINOLINE HBR](/CAS/20180601/GIF/1192352-33-2.gif)
1192352-33-2
4 suppliers
inquiry
Yield:1192352-33-2 0.28 g
Reaction Conditions:
with hydrogen bromide in acetic acid; for 2 h;Reflux;
Steps:
4-(Bromomethyl)isoquinoline hydrobromide
Isoquinolin-4-ylmethanol (0.2 g, 1.26 mmol, Eq: 1.00) was combined with AcOH (5 mL).33 %, HBr in AcOH (11.9 g, 8 mL, 48.6 mmol, Eq: 38.7) was added. The mixture was heated atreflux for 2 h during which time a precipitate formed. The mixture was cooled, diluted with ether10 and filtered. The filter cake was washed with ether and dried to give the title compound (0.28 g,white solid) which was used without purification.
References:
WO2014/9495,2014,A1 Location in patent:Page/Page column 57