4-bromothieno[2,3-c]pyridine-2-carboxylic acid synthesis
- Product Name:4-bromothieno[2,3-c]pyridine-2-carboxylic acid
- CAS Number:1151512-25-2
- Molecular formula:C8H4BrNO2S
- Molecular Weight:258.09
![4-BROMOTHIENO[2,3-C]PYRIDINE-2-CARBOXYLIC ACID METHYL ESTER](/CAS/GIF/145325-40-2.gif)
145325-40-2
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Yield:1151512-25-2 92%
Reaction Conditions:
with lithium hydroxide monohydrate;water in tetrahydrofuran at 20; for 3 h;
Steps:
40.2 Step : 4-Bromothieno[2,3-c]pyridine-2-carboxylic acid (26'-2)
A mixture of compound 26'-1 (300mg), tetrahydrofuran (1mL), water (1mL) and lithium hydroxide monohydrate (92mg) was stirred at room temperature for 3 hours, adjusted to pH=7 with 2M hydrochloric acid, extracted with ethyl acetate, and the organic phase Concentrate to dryness to obtain 261 mg of 4-bromothieno[2,3-c]pyridine-2-carboxylic acid (26'-2) as a white solid with a yield of 92%.
References:
CN112724127,2021,A Location in patent:Paragraph 0814; 0819-0821
70201-42-2
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2365-48-2
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625-92-3
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