ChemicalBook CAS DataBase List 4-(CarboxyMethoxy)-benzoic acid Methyl ester

4-(CarboxyMethoxy)-benzoic acid Methyl ester synthesis

6synthesis methods

Product Name:4-(CarboxyMethoxy)-benzoic acid Methyl ester
CAS Number:90812-66-1
Molecular formula:C10H10O5
Molecular Weight:210.18

35005-30-2
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4-(CarboxyMethoxy)-benzoic acid Methyl ester

90812-66-1
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$45.00/10mg

Yield:90812-66-1 93.8%

Reaction Conditions:

with methanol;lithium hydroxide in tetrahydrofuran at 20; for 48 h;Cooling with ice;

Steps:

1 Synthesis of 2-(4-(methoxycarbonyl)phenoxy)acetic acid (1B)

Compound 1A (1.71g, 7.63mmol)Dissolve in 5mL methanolAnd 5mL THF mixed solvent,Add in batches under ice bath conditionsLithium hydroxide (0.2g, 8.41mmol),Remove the ice bath,Reaction at room temperature for 2d,Remove the solvent under reduced pressure,Add 10mL water,Adjust the pH to 4 with dilute hydrochloric acid,Ethyl acetate extraction (3×15mL),Wash with saturated brine,Dry with anhydrous sodium sulfate,Filter, concentrate under reduced pressure,To obtain 1.50g of white solid,Yield 93.8%

References:

CN112778154,2021,A Location in patent:Paragraph 0093; 0094; 0097; 0098

99-76-3 Synthesis