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4-chloro-1-phenyl-3-nitro-2(1H)-quinolone synthesis

5synthesis methods
4-chloro-1-phenyl-3-nitro-2(1H)-quinolone

110254-64-3
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Yield:-

Steps:

Multi-step reaction with 2 steps
1: 1.) NaH / 1.) dimethylacetamide, 2.) dimethylacetamide, 170 deg C, 2 h
2: POCl3 / 0.5 h / Heating

References:

Suzuki, Fumio;Kuroda, Takeshi;Kawakita, Takashi;Manabe, Haruhiko;Kitamura, Shigeto;et al. [Journal of Medicinal Chemistry,1992,vol. 35,# 26,p. 4866 - 4874]