4-Chloro-2-(1-piperidinyl)quinazoline, 97% synthesis

6synthesis methods

Product Name:4-Chloro-2-(1-piperidinyl)quinazoline, 97%
CAS Number:134962-82-6
Molecular formula:C13H14ClN3
Molecular Weight:247.72

626-67-5 Synthesis

626-67-5
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$15.00/25g

607-68-1 Synthesis

607-68-1
310 suppliers
$10.00/1g

4-Chloro-2-(1-piperidinyl)quinazoline, 97%

134962-82-6
10 suppliers
$517.00/1g

Yield:134962-82-6 72%

Reaction Conditions:

in 1,4-dioxane at 150; for 0.0833333 h;Microwave irradiation;

Steps:

1.3

2,4-Dichloroquinazoline (1.5 g, 7.5 mmol) was dissolved in 1,4-dioxane (15 mL). N-Methylpiperidine (961 L, 7.9 mmol) was added and the mixture was heated to 150° C. for 5 min under microwave irradiation. The mixture was diluted with EtOAc and washed with saturated aqueous NaHCO₃and brine (×2). The organic layer was dried (MgSO₄), filtered and concentrated in vacuo. The crude product was purified by column chromatography (5% EtOAc-petrol) to afford the title compound as a yellow oil that solidified on evaporation from petrol to a yellow solid (1.33 g, 72%).¹H NMR (DMSO): 7.95-7.91 (1H, m), 7.77 (1H, ddd, J 8.5, 7.0 and 1.4), 7.54-7.49 (1H, m), 7.32 (1H, ddd, J 8.1, 7.0 and 1.1), 3.84-3.79 (4H, m) and 1.69-1.51 (6H, m).

References:

US2010/317607,2010,A1 Location in patent:Page/Page column 24

626-67-5 Synthesis

626-67-5
215 suppliers
$15.00/25g