4-CHLORO-2-(3-PYRIDYL)-6-METHYL PYRIMIDINE synthesis
- Product Name:4-CHLORO-2-(3-PYRIDYL)-6-METHYL PYRIMIDINE
- CAS Number:83551-42-2
- Molecular formula:C10H8ClN3
- Molecular Weight:205.64
16879-57-5
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83551-42-2
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Yield:83551-42-2 70%
Reaction Conditions:
with trichlorophosphate at 100; for 4 h;
Steps:
4-chloro-6-methyl-2-(pyridin-4-yl)pyrimidine (9)
A mixture of pyrimidinone 5 (3.8 g, 20.3 mmol) in neat phosporyl chloride (19g) was stirred at 100 °C for 4 h. Upon concentrating of the reaction mixtureunder vacuum, the oily residue was poured onto ice and stirred vigorously. Afteradjustment of pH to 7 the mixture was extracted with DCM (3×10 mL).Combined organic layers were washed with water, brine and evaporated to dryness. A columnchromatography (eluent EtOAc) afforded 2.96 g (71%) of yellowish solid;
References:
Ko?í?ek, Milan;?těpánek, Ond?ej;Parkan, Kamil;Berenguer Albi?ana, Carlos;Pávová, Marcela;Weber, Jan;Kr?usslich, Hans-Georg;Konvalinka, Jan;Machara, Ale? [Bioorganic and Medicinal Chemistry Letters,2016,vol. 26,# 15,p. 3487 - 3490] Location in patent:supporting information
16879-57-5
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83551-42-2
16 suppliers
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100-54-9
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83551-42-2
16 suppliers
$45.00/50mg