4-CHLORO-2,6-DIFLUOROBENZYL ALCOHOL synthesis

2synthesis methods

Product Name:4-CHLORO-2,6-DIFLUOROBENZYL ALCOHOL
CAS Number:288154-93-8
Molecular formula:C7H5ClF2O
Molecular Weight:178.56

Benzoic acid, 2-chloro-4,5-difluoro-, Methyl ester

128800-36-2
43 suppliers
$45.00/50mg

288154-93-8
27 suppliers
$28.60/25MG

Yield:288154-93-8 85.2%

Reaction Conditions:

Stage #1: 2-Chloro-4,5-difluorobenzoic acid methyl esterwith lithium aluminium tetrahydride in tetrahydrofuran at 20; for 4 h;
Stage #2: with water;sodium sulfate in tetrahydrofuran; for 0.5 h;

Steps:

14.2

Step 2 Preparation of (2 chloro-4 5-dιfluoro-phenyl)-methanol (120) [0181] To 2-chloro-4,5-difluoro-benzoic acid methyl ester (119, 5 70 g, 0 0276 mol) in lelrahydrofuran ( 120 0 mL), 1 00 M of lithium tetrahydroalummate in tetrahydrofuran (30 0 mL) was added slowly under an atmosphere of nitrogen The reaction was stirred at room temperature for 4 hours, followed by adding sodium sulfate decahydrate After 30 minutes, the reaction mixture was filtered, concentrated and purified with silica gel column chromatography elutmg with 8% methanol in dichloromethane to give a white solid (120, 4 20 g, 85.2%),

References:

WO2008/80001,2008,A2 Location in patent:Page/Page column 76-77

110877-64-0 Synthesis

110877-64-0
224 suppliers
$5.00/1g

288154-93-8
27 suppliers
$28.60/25MG

References