ChemicalBook CAS DataBase List 4-CHLORO-2-(CHLOROMETHYL)-1-METHOXYBENZENE

4-CHLORO-2-(CHLOROMETHYL)-1-METHOXYBENZENE synthesis

7synthesis methods

Product Name:4-CHLORO-2-(CHLOROMETHYL)-1-METHOXYBENZENE
CAS Number:7035-11-2
Molecular formula:C8H8Cl2O
Molecular Weight:191.05

7035-10-1
31 suppliers
$190.00/1g

4-CHLORO-2-(CHLOROMETHYL)-1-METHOXYBENZENE

7035-11-2
19 suppliers
$318.00/1g

Yield:7035-11-2 98%

Reaction Conditions:

with thionyl chloride in dichloromethane at 0 - 20; for 16.1667 h;

Steps:

44.5

4-Chloro-2-chloromethyl-1-methoxy-benzene, used in step 1, was prepared as follows: A cooled (0° C.) solution of (5-chloro-2-methoxy-phenyl)-methanol (4.54 g, 26.3 mmol) in dichloromethane (50 mL) was treated with thionyl chloride (2.01 mL, 27.7 mmol), which was added dropwise over 10 min. The mixture was stirred at room temperature for 16 h, then partitioned between diethyl ether and water. The organic phase was dried with sodium sulphate and evaporated. The residue was pure 4-chloro-2-chloromethyl-1-methoxy-benzene, 4.93 g (98%), and was used as such.

References:

US2008/103182,2008,A1 Location in patent:Page/Page column 21