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4-Chloro-2-cyclobutylquinazoline synthesis

3synthesis methods
4-Hydroxy-2-(cyclobutyl)quinazoline

496867-71-1
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4-Chloro-2-cyclobutylquinazoline

1095559-57-1
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Yield:1095559-57-1 15.6 g

Reaction Conditions:

with N,N-diethylaniline;trichlorophosphate in benzene; for 2 h;Inert atmosphere;Reflux;

References:

Fekner, Tomasz;Mueller-Bunz, Helge;Guiry, Patrick J. [European Journal of Organic Chemistry,2008,# 30,p. 5055 - 5066] Location in patent:experimental part