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4-Chloro-2-Methoxy-5-sulfaMoylbenzoic acid synthesis

2synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 2 steps
1: 88 percent / ClSO3H / 2 h / 60 - 70 °C
2: 89 percent / 28 percent aq. NH3 / 2 h / 40 - 50 °C

References:

Hirokawa, Yoshimi;Harada, Hiroshi;Yoshikawa, Takashi;Yoshida, Naoyuki;Kato, Shiro [Chemical and Pharmaceutical Bulletin,2002,vol. 50,# 7,p. 941 - 959]