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ChemicalBook CAS DataBase List 4-Chloro-2-(methylsulfonyl)pyrimidine

4-Chloro-2-(methylsulfonyl)pyrimidine synthesis

2synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 2 steps
1: POCl3 / 80 °C
2: 3-chloroperoxybenzoic acid / CH2Cl2 / -5 - 20 °C

References:

Davey, David D.;Adler, Marc;Arnaiz, Damian;Eagen, Keith;Erickson, Shawn;Guilford, William;Kenrick, Margaret;Morrissey, Michael M.;Ohlmeyer, Mike;Pan, Gonghua;Paradkar, Vidyadhar M.;Parkinson, John;Polokoff, Mark;Saionz, Kurt;Santos, Cecile;Subramanyam, Babu;Vergona, Ron;Wei, Robert G.;Whitlow, Marc;Ye, Bin;Zhao, Zuchun;Devlin, James J.;Phillips, Gary [Journal of Medicinal Chemistry,2007,vol. 50,# 6,p. 1146 - 1157]

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